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In his RSC Chemical Biology review article, “Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: Overlapping biology with cancer,” Balaraman Kalyanaraman, PhD, professor and chair of biophysics and the Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research, analyzes published literature linking the different mechanisms focused on oxidative stress and inflammation that contribute to COVID-19 disease severity.
The objective of the article is to compile the potential proinflammatory mechanisms of COVID-19 pathogenesis and address mitigation strategies using naturally occurring compounds and FDA-approved drugs. Repurposing drugs that already have been FDA-approved to mitigate inflammation and immunosuppression in cancer may be a way to counteract disease severity, progression, and chronic inflammation in individuals with COVID-19. Addressing the oxidative chemical biology of COVID-19 and the mechanistic commonalities with cancer may provide new insights that potentially will lead to appropriate clinical trials and new treatments for COVID-19.
This article is available on the RSC Chemical Biology website.